Yehea Ismail is the director of the Nanoelectronics and Devices Center at the American University in Cairo and Zewail City. He was a tenured professor with Northwestern University, USA from 2000 till 2011. Professor Ismail was the Editor-in-Chief of the IEEE Transaction on Very Large Scale Integration (TVLSI) 2011-2015 and the chair elect of the IEEE VLSI technical committee. He is on the editorial board of the Journal of Circuits, Systems, and Computers, was on the editorial board of the IEEE Transactions on Circuits and Systems I: Fundamental Theory and Applications, and a guest editor for a special issue of the IEEE Transactions on Very Large Scale Integration (VLSI) Systems on "On-Chip Inductance in High Speed Integrated Circuits". He has also chaired many conferences such as GLSVLSI, IWSOC, ISCAS. He was the Chief Scientist of the Innovation and Entrepreneurship Center of the Ministry of Communications and Information Technology, Egypt

Professor Ismail has several awards such as the USA National Science Foundation Career Award, the IEEE CAS Outstanding Author Award, Best Teacher Award at Northwestern University, and many other best teaching awards and best paper awards. Professor Ismail is the distinguished lecturer of IEEE CASS. He is an IEEE Fellow.

Professor Ismail has published more than 300 papers in top refereed journals and conferences and many patents. He co-authored seven books including: On-Chip Inductance in High Speed Integrated Circuits, Handbook on Algorithms for VLSI Physical Design, Temperature-Aware Computer Architecture, Arbitrary Modeling of TSVs for 3D Integrated Circuits, and Circuit Design Techniques for Microscale Energy Harvesting Systems. He has many patents in the area of high performance circuits and interconnect design and modeling. His work is some of the most highly cited in the VLSI area and is extensively used by industry.

1. Ahmed El-Badawy, Marwa Amer, Reda Abdelbaset, Sameh N.Sherif, Marwan Abo-Elela, Yehya H.Ghallab, Hamdy Abdelhamid, Yehea Ismail, Nagwa El-Badri, "Adipose Stem Cells Display Higher Regenerative Capacities and More Adaptable Electro-Kinetic Properties Compared to Bone Marrow-Derived Mesenchymal Stromal Cells", Springer Nature Research Journal, November 2016.
2. Ghallab, Y.H.; Abd El-Hamid, H.; Ismail, Y., "Lab on a Chip Based on CMOS Technology: System Architectures, Microfluidic Packaging, and Challenges," in Design & Test, IEEE , vol.32, no.6, pp.20-31, Dec. 2015 doi: 10.1109/MDAT.2015.2491785 Ahmad Qassem, Reda Mohamed, Yehya Ghallab, Yehea Ismail, "A 130 nm CMOS Integrated Lab-On-a-Chip Based on DeFET Sensor for Biomedical Analysis", MWSCAS 2016, October 2016, Abu Dhabi
3. Reda Abdelbaset, Yehya Ghallab, Hamdy Abdelhamid, Yehea Ismail and Mohamed Elwakad, "A 2D Model of Traveling Wave Dielectrophoresis Microelectrode Array based on Printed Circuit Board Technology for manipulation and characterization of Malignant and Normal Liver Cells", Fourth International Japan-Egypt Conference on Electronics, Communications and Computers (JEC-ECC 2016)
4. Yehya H. Ghallab and Yehea Ismail" CMOS Based Lab-on-a-chip: 'Applications, Challenges and Future Trends", published at IEEE Circuit and Systems Magazine, pp. 27-47, Q2 issue, June 2014.

Purpose: To demonstrate the electroretinography (ERG) and histology of eyes of minipig after long-term bimplantation of wireless photovoltaic subretinal prostheses.

Methods: A series of the retinal prosthesis chip was designed and fabricated. Among the prostheses were an 8x8 pixels and another 16x16 pixels array. Each pixel was fabricated with parallel micro photodiodes, equipped with a pair of an independent output electrode and an adjacent return electrode. The prostheses were powered by on-chip solar cells, and embedded with a unique circuit, i.e. division-power-supply-scheme (DPSS), inspired by flicker fusion. Some of the prostheses were further packed with hermetic packaging. The prostheses were examined through a series of biosafety and biocompatibility tests. The photovoltaic subretinal prostheses were implanted to minipigs. Mostly, the implantation was performed through the choroid approach. ERG was performed with different protocols (Roland, Germany). Histological examination was done after enucleation.

Results: The 8x8 pixels array prostheses had been implanted for 2 years, and the 16x16 pixels array for 7 months. The prostheses stayed well in the subretinal space of the posterior fundus. ERG showed significant b-wave responses after bleaching in the implanted eye, whereas the control eye showed flat response. The histological examination showed relatively preserved inner layer of the retina.

Conclusions: The electrophysiology and biocompatibility of a novel 64 pixels and a 256 pixels photovoltaic subretinal prosthesis with DPSS are primarily verified through the long-term implantation to minipigs. The prostheses bear potential to enter future clinical trials.

Po-Kang Lin, MD was graduated from National Yang Ming University, ROC, 1985. He was a resident, chief resident, and a research fellow in Taipei Veterans General Hospital, ROC from 1987-1990, 1990-1991, 1991-1993, respectively. Since 1993, Doctor Lin has been a retina staff in the Department of Ophthalmology in Taipei Veterans General Hospital, ROC. From 1994 to1995, he was a research fellow in Columbia University, USA. Now he is a researcher of the Biomedical Electronics Translational Research Center (BETRC), National Chiao Tung University, ROC. He is also a clinical professor in National Defense Medical University, ROC, since 2012, and an associate professor of ophthalmology in National Yang Min University. His current research fields are clinical ophthalmology, biomedical electronics, focused-ion-beam for biology, and retina: biological, medical, and surgical.

1. Hui-Chen Cheng, Shui-Mei Lee, Fenq-Lih Lee, Jorn-Hon Liu, Chieh-Hsiung Kuan, Po-Kang Lin*. 2013. Short-term external buckling with pneumatic retinopexy for retinal detachment with inferior retinal breaks. American Journal of Ophthalmology‏ 155(4): 750-756. (correspondent)
2. Po-Kang Lin*, Chia-Ying Ke, Chin-Ni Khor, Yu-Jyun Cai, Yih-Jing Lee*. 2013. Involvement of SDF1a and STAT3 in granulocyte colony-stimulating factor rescues optic ischemia-induced retinal function loss by mobilizing hematopoietic stem cells. Investigative Ophthalmology & Visual Science 54(3): 1920-1930
3. Hui-Chen Cheng, Jorn-Hon Liu, Shui-Mei Lee, Po-Kang Lin*. 2014. Hyperhomocysteinemia in Patients with Polypoidal Choroidal Vasculopathy: A Case Control Study. PLoS ONE 9(10): e110818. (correspondent)
4. Shih-Yun Lee, Wei-Kuang Yu, Po-Kang Lin*. 2015. Large Gene Deletion and Changes in Corneal Endothelial Cell in a Family with Choroideremia. Investigative Ophthalmology & Visual Science 56(3): 1887-1893. (correspondent)
5. Hui-Chen Cheng, Shui-Mei Lee, Yi-Ting Hsieh, Po-Kang Lin*. 2015. Efficacy of intravitreal injection of anti-vascular endothelial growth factor agents for stage 4 retinopathy of prematurity. RETINA-The Journal of Retinal and Vitreous Diseases 35(4): 660-666. (correspondent)

The working principle of the artificial ear is based on the frequency topology of the cochlea (Tonotopy). Frequency topology is a regular relationship between different parts of the cochlea and different sound frequencies. In normal hearing systems, the mechanical vibration of the sound through the outer ear and middle ear, in the cochlea within the liquid within the tube to form a traveling wave, traveling wave in the cochlea throughout the basement membrane resonance. According to the frequency of different basement membrane in different parts of the maximum amplitude of resonance. The high-frequency sound produces a maximum resonance amplitude at the base film near the bottom (i.e., near the round window), and the maximum resonance amplitude of the low-frequency sound is produced at the portion of the base film near the top (i.e., away from the window). The vibrations of the basement membrane drive hair cell cilia vibration to produce hair cell receptor potential, thereby generating the auditory nerve action potential release. The auditory nerve inherits the frequency topological properties of the cochlea. The frequency topology is a means by which the auditory system decomposes the sound into different frequency components. Brain central auditory system can be based on the auditory nerve in the distribution of different nerve fibers to determine the basement membrane vibration, and the frequency of sound components. Genetic factors, the role of ototoxic drugs, meningitis disease, as well as by the noise of the destruction of noise, are caused by some patients with sensory nerve deafness, hair cells were reduced or the number of possible causes of injury. Remnant hair cells can't properly stimulate the auditory nerve. The cochlear implant is to bypass the hair cells in this part of the direct electrical stimulation of the auditory nerve. For the brain, the electrical stimulus works as if the auditory nerve is being driven by the normal basal membrane and hair cells. This is the basic working principle of artificial electronic ears.

When a person's hearing loss, while other hearing aids without a big help, they should consider using artificial electronic ear. Especially hearing impaired children, can't help with hearing aids, should be considered as soon as possible to accept artificial electronic ear implantation surgery, usually hearing the shorter the time the better. If prolonged, especially for children with complete deafness, will increase the difficulty of post-operative education, and reduce the effect after surgery. Taiwan has entered the aging society, many elderly people have hearing problems, however, not everyone is suitable for hearing aids to wear. Physicians pointed out that the hearing loss of more than 80 decibels or more, the best choice of artificial ear, domestic artificial ear technology is mature, using minimally invasive surgery, postoperative wound is not swollen to revitalize the hospital for nearly 10 years 350 cases The youngest only 10 months, the largest is 86 years old, all patients are not present infection problems, the success rate of 100%, more land-based from Heilongjiang, Inner Mongolia and other places come here especially. Last year, the Department of Health subsidized newborns within 36 hours after birth, hearing screening, help early detection, and the artificial ear surgery, the Department of Health only subsidize children under the age of 6, the elderly are not subsidized.
Keyword: Artificial ear, hearing aid, hearing impairment, hearing examination

1. Lee Chia-Fone, Chen Peir-Rong, Lee Wen-Jeng, Chen Jyh-Horng, Liu Tien-Chen, "Three-dimensional reconstruction and modeling of middle ear biomechanics by high-resolution computed tomography and finite element analysis", Laryngoscope (SCI), 116: 711-716, 2006.
2. Lee Chia-Fone, Chen Jyh-Horng, Chou Yuan-Fang, Hsu Lee-Ping, Chen Peir-Rong, Liu Tien-Chen, "Optimal graft thickness for different sizes of tympanic membrane perforation in cartilage myringoplasty: a finite element analysis", Laryngoscope (SCI), 117:725-730, 2007.
3. Lee Chia-Fone, Hsu Lee-Ping, Chen Peir-Rong, Chou Yuan-Fang, Chen Jyh-Horng, Liu Tien-Chen, "Biomechanical modeling and design optimization of cartilage myringoplasty using finite element analysis", Audiology & Neurotology (SCI), 11: 380-388, 2006.
4. Lee Chia-Fone, Chen Peir-Rong, Lee Wen-Jen, Chou Yuan-Fang, Chen Jyh-Horng, Liu Tien-Chen, "Computer aided modeling of human mastoid cavity biomechanics using finite element analysis, "EURASIP Journal on advances in Signal Processing. Special Issue: Image processing and analysis in biomechanics (SCI), 1-9: 2009.
5. Lee Chia-Fone, Li Gen-Jia, Wan Shu-Yen, Lee Wen-Jeng, Tzen Kai-Yuan, Chen Chiung-Hsiang, Song Yu-Lin, Chou Yuan-fang, Chen Yuh-Shyang, Liu Tien-Chen," Registration of micro-computed tomography and histological images of guinea pig cochlea to construct an ear model using an iterative closet point algorithm", Annals of biomedical Engineering (SCI), 38(5): 1717-1727, 2010.

Neuromodulation, or neurostimulation, is a palliative treatment option for many of these patients who are not eligible for resective surgery or who have persistent medically intractable refractory seizures despite previous epilepsy surgery. Patients typically have partial onset seizures, with or without secondary generalization, or less frequently, generalized epilepsies. Candidates for neuromodulation usually have a long-standing history of intractable epilepsy and have undergone extensive investigations, including video- electroencephalography (EEG), advanced neuroimaging, and even intracranial subdural or depth electrode implantations for seizure localization in many cases. Most of these patients have been found to have no single discrete seizure onset localization; a minority has seizure onsets localized to indispensable areas of eloquent cortex, for example, within the boundaries of language centers in the dominant temporal or frontal cortices. Neuromodulation as an alternate form of treatment for intractable epilepsy was first considered based on historical observations that electrical stimulation of subcortical structures could modify the cortical EEG: high-frequency stimulation "de- synchronized" the EEG and low-frequency stimulation "synchronized" the EEG. Increased cortical synchrony mediated by low-frequency stimulation was demonstrated to be proepileptic, while cortical desynchronization mediated by high-frequency stimulation was shown to be anti- epileptic.

In this talk, some historical highlights of the surgery of epilepsy will be reviewed. The current available tools as neuromodulation for seizure control will be addressed. In addition, emerging techniques will be introduced. However, further development and clinical experience to optimize the place of non-medical therapy are required.

Dr. Yue-Loong Hsin graduated in 1986 from medicine of school, Kaohsiung medical university. In 1998, he finished his residency training of neurology and was qualified as neurology specialist. Since he visited department of brain pathophysiology at Kyoto University in 1999, he focused on treatment of epilepsy and neurophysiology research about epilepsy. After Dr. Harnod Tomor became a member of neuroscience center at Hualien Tz Chi hospital, the first epilepsy surgery was conducted in 2000. By far, over 100 patients underwent epilepsy surgeries and had significant improvement of seizure control. Besides, clinical and basic researches about the pathophysiology of epilepsy are also in progress. Moreover, Dr. Hsin is interested in studying the temporospatial dysnamics of epileptic activity and connectivity of normal and abnormal brain functions. Currently he is the chairman of neurologic department at Chung Shan Medical University.

1. S.-J. Peng, T. Harnod, J. Z. Tsai, C. C. Huang, M. D. Ker, J. C. Chiou, H. Chiueh, C. Y. Wu and Y. L. Hsin, "Through diffusion tensor magnetic resonance imaging to evaluate the original properties of neural pathways of patients with partial seizures and secondary generalization by individual anatomic reference atlas," Biomed. Res. Int., vol. 2014, pp. 419376, 2014.
2. S.-J. Peng, T. Harnod, J. Z. Tsai, M. D. Ker, J. C. Chiou, H. Chiueh, C. Y. Wu and Y. L. Hsin, "Evaluation of subcortical grey matter abnormalities in patients with MRI-negative cortical epilepsy determined through structural and tensor magnetic resonance imaging," BMC Neurol., vol. 14, pp. 104-2377-14-104, May 14, 2014.
3. J. Z. Tsai, S.-J. Peng, Y. W. Chen, K. W. Wang, C. H. Li, J. Y. Wang, C. J. Chen, H. J. Lin, E. E. Smith, H. K. Wu, S. F. Sung, P. S. Yeh and Y. L. Hsin, "Automated segmentation and quantification of white matter hyperintensities in acute ischemic stroke patients with cerebral infarction," PLoS One, vol. 9, pp. e104011, Aug 15, 2014.
4. J. Z. Tsai, S.-J. Peng, Y. W. Chen, K. W. Wang, H. K. Wu, Y. Y. Lin, Y. Y. Lee, C. J. Chen, H. J. Lin, E. E. Smith, P. S. Yeh and Y. L. Hsin, "Automatic detection and quantification of acute cerebral infarct by fuzzy clustering and histographic characterization on diffusion weighted MR imaging and apparent diffusion coefficient map," Biomed. Res. Int., vol. 2014, pp. 963032, 2014.
5. S.-J. Peng and Y.-L. Hsin, "Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures," NeuroImage: Clinical, vol. 13, pp. 55-61, 2016.

Increasing evidence showed that Parkinsonism symptom is associated with neuronal activities oscillating at β band (13-35 Hz) at subcortical level. The aim of this project is to apply a novel closed-loop DBS to patients with its stimulation triggered by β band local field potentials (LFP) recorded from subcortical, as well as to examine whether the new system is more effective than the conventional DBS.

In this talk, the current status of DBS therapy for PD and the possible development of new closed-loop DBS will be discussed.

1. Chen CC*, Lin WY*, Chan HL, Tu PH, Lee ST, Lu CS, Brown P., "The impact of low-frequency stimulation of subthalamic region on self-generated isometric contraction in patients with Parkinson's disease.", Experimental Brain Research, 2013; 227(1):53-62.
2. Chen CC*, Wey Yil Lin*, Hsiao Lung Chan, Yi Ting Hsu, Po Hsun Tu, Shih Tseng Lee, Shang Ming Chiou, Chon Haw Tsai d, Chin Song Lu and Peter Brown., "Stimulation of the subthalamic region at 20 Hz slows the development of grip force in Parkinson's disease.", Experimental Neurology, 2011; 231(1):91-6.
3. Chen CC*, Hsu YT, Chan HL, Chiou SM, Tu PH, Lee ST, Tsai CH, Lu CS, Brown P., "Complexity of subthalamic 13-35 Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease", Experimental Neurology, 2010 ;224(1):234-40.
4. Chen CC, Bruck C, Kempf F, Kupsch A, Lu CS, Lee ST, Tisch S, Limousin P, Hariz M and Brown P.*, "Deep brain stimulation of the subthalamic nucleus: a two edged sword", Current Biology, 2006; 16(22):R952-3.
5. Brown P*, Chen CC, Wang S, Kuhn A, Doyle L, Yarrow K, Stin J, Aziz T., "Involvement of human Basal Ganglia in off-line feed-back control of voluntary movement", Current Biology, 2006; 16(21):2129-34.

Sheng-Yu Peng received the B.S. and M.S. degrees in Electrical Engineering from the National Taiwan University, Taipei, Taiwan, in 1995 and 1997 respectively; a degree of Master of Science in Electrical and Computer Engineering from the Cornell University, Ithaca, NY, in 2004; and the Ph.D. degree in Electrical and Computer Engineering from the Georgia Institute of Technology, Atlanta, GA, in 2008. From 2008 to 2011, he worked for GTronix Inc. and MaxLinear Inc. respectively.

Dr. Peng joined the National Taiwan University of Science and Technology, Taipei, Taiwan, in 2011. Currently he is an Associate Professor in the Department of Electrical Engineering. His research interests include interface circuits for sensors, reconfigurable analog circuits and systems, power-efficient analog signal processing, and low-power machine learning algorithms.

1. S.-Y. Peng*, L.-H. Liu, P.-K. Chang, T.-Y. Wang, and H.-Y. Li, "A Power-Efficient Reconfigurable Output-Capacitor-Less Low-Drop-Out Regulator for Low-Power Analog Sensing Front-End," IEEE Transactions on Circuits and Systems I: Regular Papers, accepted in Apr. 2016. (SCI, EI) (Impact factor: 2.403, Rank factor: 39/249, (ENGINEERING, ELECTRICAL & ELECTRONIC))
2. T.-Y. Wang, L.-H. Liu, and S.-Y. Peng*, "A Power-Efficient Highly-Linear Reconfigurable Biopotential Sensing Amplifier Using Gate-Balanced Pseudo Resistors," IEEE Transactions on Circuits and Systems II: Express Briefs, vol. 62, no. 2, pp. 199-203, Feb. 2015. (SCI, EI) (Impact factor: 1.234, Rank factor: 126/249, (ENGINEERING, ELECTRICAL & ELECTRONIC))
3. T.-Y. Wang, M.-R. Lai, C. M. Twigg, and S.-Y. Peng*, "A Fully Reconfigurable Low-Noise Biopotential Sensing Amplifier With 1.96 Noise Efficiency Factor," IEEE Transactions on Biomedical Circuits and Systems, vol. 8, no. 3, pp. 411-422, June 2014. (SCI, EI) (Impact factor: 2.482, Rank factor: 34/249, (ENGINEERING, ELECTRICAL & ELECTRONIC))
4. S.-Y. Peng*, M. S. Qureshi, P. E. Hasler, A. Basu, and F. L. Degertekin, "A Charge-Based Low-Power High-SNR Capacitive Sensing Interface Circuit," IEEE Transactions on Circuits and Systems I: Regular Papers, Vol. 55, No. 7, pp. 1863 – 1872, Aug. 2008. (SCI, EI) (Impact factor: 2.043, Rank factor: 56/229, (ENGINEERING, ELECTRICAL & ELECTRONIC))
5. S.-Y. Peng*, P. E. Hasler, and D. V. Anderson, "An Analog Programmable Multidimensional Radial Basis Function Based Classifier," IEEE Transactions on Circuits and Systems I: Regular Papers, Vol. 54, No. 10, pp. 2148 – 2158, Oct. 2007. (SCI, EI) (Impact factor: 1.204, Rank factor: 66/227, (ENGINEERING, ELECTRICAL & ELECTRONIC))

Jeremy is an assistant professor at National Tsing Hua University, Taiwan. He has been a member of Signal Analysis and Interpretation Laboratory (SAIL) at USC directed by Prof. Shrikanth Narayanan and obtained his PhD degree in Electrical Engineering in December 2012. Jeremy was a data scientist at id:a lab at ID Analytics, inc from Feb. 2013 - Dec. 2013. His research interests are in human-centered behavioral signal processing, emphasizing the development of computational frameworks in recognizing and quantifying human behavioral attributes and interpersonal interaction dynamics using machine learning and signal processing techniques. He has been involved in multiple interdisciplinary research projects and has conducted collaborative research with researchers across domains of behavioral sciences.

1. Daniel Bone, Chi-Chun Lee, Matthew Black, Marian Williams, Sungbok Lee, Pat Levitt, and Shrikanth S. Narayanan, "The Psychologist as an Interlocutor in ASD Assessment: Insights from a Study of Spontaneous Prosody", in: Journal of Speech, Language, and Hearing Research, 57(4): 1162-77, 2014, doi: 10.1044/2014_JSLHR-S-13-0062
2. Chi-Chun Lee, Athanasios Katsamanis, Matthew Black, Brian Baucom, Andrew Christensen, Panayiotis G. Georgiou, and Shrikanth S. Narayanan, "Compute Vocal Entrainment: A Signal-Derived PCA-based Quantification Scheme with Application for Affect Analysis in Married Couple Interactions ", in: Journal of Computer Speech and Language, 28(2): 518-539 doi:10.1016/j.csl.2012.06.006
3. Fu-Sheng Tsai, Ya-Ling Hsu, Wei-Chen Chen, Yi-Ming Weng, Chip-Jin Ng,Chi-Chun Lee, "Toward Development and Evaluation of Pain Level-Rating Scale for Emergency Triage based on Vocal Characteristics and Facial Expressions" in Proceedings of the International Speech Communication Association (Interspeech), 2016
4. Hsuan-Yu Chen, Yu-Hsien Liao, Heng-Tai Jan, Li-Wei Kuo, Chi-Chun Lee, "A Gaussian Mixture Regression Approach toward Modeling the Affective Dynamics between Acoustically-derived Vocal Arousal Score (VC-AS) and Internal Brain fMRI BOLD Signal Response" in Proceedings of the International Conference on Acoustics, Speech, and Signal Processing (ICASSP), 2016
5. Shan-Wen Hsiao, Hung-Ching Sun, Ming-Chuan Hsieh, Ming-Hsueh Tsai, Hsin-Chih Lin, Chi-Chun Lee, "A Multimodal Approach for Automatic Assessment of School Principals' Oral Presentation During Pre-service Training Program" in Proceedings of the International Speech Communication Association (Interspeech), 2015

1. Chin-Yu Lin, Yao-Horng Wang, Kuei-Chang Li, Li-Yu Sung, Chia-Lin Yeh, Kun-Ju Lin, Tzu-Chen Yen, Yu-Han Chang, Yu-Chen Hu. 2015. Healing of massive segmental femoral bone defects in minipigs by allogenic ASCs engineered with FLPo/Frt-based baculovirus vectors. Biomaterials 50: 98-106. (SCI: IF=8.312, based on 2013 JCR)
2. Yuan-Hung Liu, Kai-Yen Peng, Yu-Wei Chiu, Yi-Lwun Ho, Yao-Horng Wang, Chia-Tung Shun, Shih-Yun Huang, Yi-Shuan Lin, Antoine A.F. de Vries, Daniël A. Pijnappels, Nan-Ting Lee, B. Linju Yen, Men-Luh Yen. 2015. Human Placenta-Derived Multipotent Cells (hPDMCs) Modulate Cardiac Injury: From Bench to Small & Large Animal Myocardial Ischemia Studies. Cell Transplantation 24:2463–2478. (SCI: IF=3.570, based on 2013 JCR)
3. Shao-Yu Peng, Yu-Shi Chen, Chih-Jen Chou1, Yao-Horng Wang, Hung-Maan Lee, Winston Teng-Kui Cheng, SW Steven Shaw, Shinn-Chih Wu. 2014. Cell fusion phenomena detected after in utero transplantation of Ds-red-harboring porcine amniotic fluid stem cells into EGFP transgenic mice. Prenatal Diagnosis 5:487-495. (SCI: IF=2.514, ranking on top 20%=16/78, based on 2013 JCR; subject categories of OBSTETRICS & GYNECOLOGY).
4. Chun-Li Wang, Ching-Kuei Chen, Yao-HorngWang, and Yu-Wen Cheng. 2014. In Search of the Active Metabolites of an Anticancer Piperazinedione, TW01003, in Rats. BioMed Research International 2014 Article ID 793504, 6 pages. http://dx.doi.org/10.1155/2014/793504
5. Chia-Chun Chen, Cheng-Hao Liao, Yao-Horng Wang, Yuan-Ming Hsu, Shih-Horng Huang, Chih-Hung Chang, and Hsu-Wei Fang. 2012. Cartilage fragments from osteoarthritic knee promote chondrogenesis of mesenchymal stem cells without exogenous growth factor induction. J Orthop Res 30:393–400 (SCI: 2.875)

Since neurons are delicate and un-regenerable, neural degenerative diseases become major problems in neurological clinic. These neural degenerative diseases, such as Alzheimer's disease, Parkinson's disease, and stroke, are usually found difficult to slow down the progress of the disease, and there is still no effective way to regain the function loss of the degenerative cells. It is therefore many researches aim on solving problems in the pathogenesis and therapy on these diseases. We will introduce animals models commonly used for these neural degenerative diseases in this section.

1. Cheng CK, Peng PH, Tien LT, Cai YJ, Chen CF, and Lee YJ* (2009): Bevacizumab is not toxic to retinal ganglion cells after repeated intravitreal injection. Retina, 29: 306-312. (SCI)
2. Hsiao WT, Tsai MD, Jow GM, Tien LT, and Lee YJ* (2012): Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. Molecular Vision, 18: 2033-2042. (SCI)
3. Tsai MD, Chen PR, Tien LT, Cai YJ, and Lee YJ* (2013): Nuclear condensation and cell cycle arrest induced by telomerase siRNA in neuroblastoma cells. Journal of Neuro-Oncology, 111: 265-272. (SCI)
4. Lin PK, Ke CY, Khor CN, Cai YJ, and Lee YJ* (2013): Involvement of SDF1a and STAT3 in granulocyte colony-stimulating factor rescues optic ischemia-induced retinal function loss by mobilizing hematopoietic stem cells. Investigative Ophthalmology & Visual Science, 54: 1920-1930. (SCI)
5. Cheng YP, Ke CY, Kuo CC, and Lee YJ* (2016): Effect of a complex lutein formula in an animal model for light-induced retinal degeneration. The Chinese Journal of Physiology, 59: 202-209. (SCI)