Deep Brain stimulation and brain research
Tsinghua University National Engineering Laboratory for Neuromodulation firstname.lastname@example.org/04/29 9:10 ~ 10:00 東館禮堂廳(5F)
Deep brain stimulation (DBS) is the only technique that can directly modulate brain activities using electrical stimulation. A vast amount of research has shown that DBS not only causes a direct effect on the target nuclei, but somehow modulates pathological oscillations that reverberate through multiple brain regions. As such, this provides great opportunities for understanding brain activity in human behaviors.
In the last decade, High frequency stimulation (HFS) has been used for the treatment of advanced Parkinson's disease (PD), which was honored by the Lasker Medical Research Award 2014. However, it is known that HFS is unable to alleviate certain symptoms, such as freezing of gait(FOG) and dysarthria. We have recently found that the combination of different frequencies can successfully treat these unmanageable symptoms, using our newly developed stimulation therapy called 'Various Frequency Stimulation (VFS)'. A clinical trial results will be presented in this talk to show the significant differences of VFS to the currently used HFS, particularly on FOG.
From HFS to VFS, a small change but a great deal of difference. There is an enormous challenge in understanding how to modulate the brain? One fact remains is that we need tools and technology. Based on many years' experience on developing implantable devices, we have established a new platform that not only provides DBS therapy but also gives concurrent measurements of local field potential signals to investigate neural circuits. This research tool is like an implanted brain recorder that may allow us to answer vital questions related with various brain disorders and different brain states in combination with behavioral evaluations. In addition, this device also has great potential for providing high clinical value, such as guiding DBS parameter programming, and finally realizing the individualized therapy in closed-loop DBS. More than 10 PD patients' sleeping data will be presented in this talk to show the difference feathers along with sleeping stage. And the results will lead to a novel close-loop stimulation—turn off the DBS when sleeping.
Another important issue in DBS neurosurgery is MRI compatibility, which not only relates to clinical practice but also brain research. During MRI scanning, the biggest challenge for the DBS practitioner is the temperature increase caused by RF fields. Several known factors including electrode, extent and device will affect the temperature. Following numerous simulations and experiments, an updated device which could be compatible with 3T MRI, not only safety to scan when turning off the power but scan while turning on also. This provides a significant tool to understand what has been happening during stimulation. In the other words to help us to know the mechanism of DBS. 10 patients' results will also be presented in this talk.
He has received a B.S. degree in Mechanical Engineering (1991) and M.S. and Ph.D. degrees in Material Science and Engineering (1996) from Tsinghua University, Beijing. As a leader of a multi-disciplinary group, he has designed and created a novel deep brain stimulation device in China for patients in developing countries. To date, the Chinese DBS system, which mediates Variable Frequency Stimulation (VFS), a uniquely different function to commonly used High Frequency Stimulation (FFS), has recently been approved and certificated by the Chinese FDA (2013) following nearly ten years of R&D.
Dr. Li has also designed and created the first implantable, rechargeable neuromodulation device in China, which was certificated in July 2014. These devices are now used in more than 110 clinical centers in China, with more than 2000 successful implantations in patients. Recently, Dr. Li also led his group in the development of the lightest Vagus Nerve Stimulator for Intractable Epilepsy treatment. This device was approved and certificated in May, 2016.
Dr. Li has previously been awarded with National Science Fund for Distinguished Young Scholars, 2011, "Top Ten Science & Technology Advances of Chinese College, 2012", and the First prize of S&T, Beijing 2015.
Dr. Li is currently the Director of National Engineering Laboratory for Neuromodulation and the vice chairman of Chinese Society of Neuromodulation.
- Fumin Jia, Yi Guo, Sen Wan, Luming Li *. Severe subthalamic stimulation-induced dysarthria alleviated by a novel paradigm: A case report\ Journal of Neurological science. 2016
- Xing Qian,Yue Chen, Yuan Feng, Luming Li *.A Method for Removal of Deep Brain Stimulation Artifact from Local Field Potentials\IEEE Transactions on Neural Systems and Rehabilitation Engineering ,2016 PP(99):1-1
- Xing Qian，Yue Chen, Bozhi Ma，Hongwei Hao，Luming Li *. Chronically monitoring the deep brain rhythms: from stimulation to recording /Science Bulletin, 2016(19):1522-1524
- Fumin Jia, Yi Guo, Sen Wan, Hao Chen, Hongwei Hao, Jianguo Zhang, Luming Li *.Variable frequency stimulation of subthalamic nucleus for freezing of gait in Parkinson's disease/Parkinsonism and related disorders, 2015, 21(12), 1471-1472
- Changqing Jiang, Xiaolong Mo, Yantao Dong, Fangang Meng, Hongwei Hao, Jianguo Zhang, Xiqiao Feng, Luming Li*. An Experimental Study of Deep Brain Stimulation Lead Fracture: Possible Fatigue Mechanisms and Prevention Approach. Neuromodulation: Technology at the Neural Interface. 2014, 18(4):243-248
- Changqing Jiang, Hongwei Hao, Luming Li *, Artifact properties of carbon nanotube yarn electrode in magnetic resonance imaging, Journal of neural engineering, 2013, 10(2), 026013.
- Shaobo Chen, Qingfeng Li, Weiming Wang, Bozhi Ma, Hongwei Hao, Luming Li*.In Vivo Experimental Study of Thermal Problems for Rechargeable Neurostimulators, Neuromodulation: Technology at the Neural Interface, 2013, (16), 436-442.
- Changqing Jiang, Luming Li *, Hongwei Hao, Carbon nanotube yarns for deep brain stimulation electrode, IEEE transactions on neural systems and rehabilitation engineering, 2011, 19(6), 612-616.
Prof. Mohammed Ismail
A Self-powered Biomedical SoC Platform for Wearable Health Care
Wayne State University Electrical and Computer Engineering email@example.com https://engineering.wayne.edu/profile/gd86862017/04/29 10:20 ~ 11:10 東館禮堂廳(5F)
This talk will focus on Systems-on-Chip (SoCs) presented as part of the UAE SRC (Semiconductor Research Corp) Center of Excellence on Energy Efficient Electronic Systems (aka ACE4S http://www.src.org/program/grc/ace4s/) involving researchers from 5 UAE Universities looking at developing new technologies aiming at innovative self-powered wireless sensing and monitoring SoC platforms. The research targets applications in self-powered chip sets for use in public health, ambient intelligence, safety and security and IoT. ACE4S is the first SRC center of excellence outside the US.
Mohammed Ismail a prolific author and entrepreneur in the field of chip design and test, spent over 25 years in academia and industry in the US and Europe .He obtained his BS and MS from Cairo University, Egypt and His PhD from the University of Manitoba, Canada in 1983, all in electrical engineering.
He is the Founder of the Ohio State University's (OSU) Analog VLSI Lab, one of the foremost research entities in the field of analog, mixed signal and RF integrated circuits and served as its Director. He also served on the Faculty of OSU's ElectroScience Lab. He held a Research Chair at the Swedish Royal Institute of Technology (KTH) where he founded the RaMSiS (Radio and Mixed Signal Integrated Systems) Research Group there. He had visiting appointments in Finland (Aalto university), Norway (NTH and University of Oslo), the Netherlands (Twente University) and Japan (Tokyo Institute of Technology).
He Joined KUSTAR, the UAE in 2011, where he held the ATIC (now Mubadala Technology) Professor Chair and is Founding Chair of the ECE Department. He is the Founding Director of the Khalifa Semiconductor Research Center (KSRC) and Co-Director of the ATIC-SRC Center of Excellence on Energy Efficient Electronic systems (ACE4S) targeting self-powered chip sets for wireless sensing and monitoring, bio chips and power management solutions. He recently joined Wayne State University, Detroit, Michigan as Professor and Chair of the ECE Department. His current research focuses on "self- healing" design techniques for CMOS RF and mm-wave ICs in deep nanometer nodes, energy harvesting and power management, wearable Biochips and SoCs for IoTs.
Dr.Ismail served as a Corporate Consultant to over 30 companies and is a Co-Founder of Micrys Inc., Columbus, Ohio, Spirea AB, Stockholm, Firstpass Technologies Inc., Dublin, Ohio and ANACAD-Egypt (now part of Mentor Graphics/Siemens).
He advised the work of over 50 Ph.D. students and of over 100 M.S. students. He authored or co-authored over 20 books and over 170 journal publications, 300 conference papers and has 14 US patents issued and several pending. He is the Founding Editor of the Springer Journal of Analog Integrated Circuits and Signal Processing and serves as the Journal's Editor-in-Chief. He served the IEEE in many editorial and administrative capacities. He is the Founder of the IEEE International Conference on Electronics, Circuits and Systems (ICECS), the flagship Region 8 Conference of the IEEE Circuits and Systems Society and a Co-Founder of the IEEE International Symposium on Quality Electronic Design (ISQED). He received the US Presidential Young Investigator Award, the Ohio State Lumley Research Award four times, in 1992, 1997, 2002 and 2007, IEEE 2016 CAS Society best paper award and the US Semiconductor Research Corporation's Inventor Recognition Award twice. He is a Fellow of IEEE.
- M. Alhawari, B. Mohammad, H. Saleh, and M. Ismail, "An Efficient Polarity Detection Technique for Thermoelectric Harvester in L-based Converters," accepted by IEEE Trans Circuits and Systems I.
- M Alhawari, B Mohammad, H Saleh, and M Ismail, "An Efficient Zero Current Switching Control for L-based DC-DC Converters in TEG Applications," accepted by IEEE Transactions on Circuits and Systems II.
- D. Kilani,M. Alhawari, B. Mohammad, H. Saleh, and M. Ismail., "An Efficient Switched-Capacitor DC-DC Buck Converter for Self-powered Wearable Electronics," IEEE Transactions on Circuits and systems I, Vol. 63, No. 10, pp. 1557-1566, Oct. 2016.
- K Eledlebi, M Ismail, and M Rezeq, "Finite element simulation and analysis of nano-metal-semiconductor contacts," Nanotechnology Reviews. Vol. 5, No. 3, pp. 355–362, May 2016.
- N. Bayasi, T. Tekeste, H. Saleh, B. Mohammad, A. Khandoker, and M. Ismail, "Low-Power ECG-Based Processor for Predicting Ventricular Arrhythmia," IEEE Transactions on Very Large Scale Integration (VLSI) Systems, Vol.24, pp. 1962-1974, May 2016. (Received the 2016 IEEE CAS Society best paper award)
Bioelectronic Medicine: The Next Big Thing
Wayne State University Department of Bioengineering2017/04/30 8:30 ~ 9:20 東館禮堂廳(5F)
Department of Electrical Engineering
Director of Chan Soon-Shiong Bionic Engineering Research Center
University of California, Los Angeles firstname.lastname@example.org http://www.seas.ucla.edu/IBR
Bioelectronic Medicine (BM) is a new field that has tremendous potential to revolutionize the medicine practice. This field fuses together of electro-chemical molecular mechanism, neuroscience, and ICT with the main mechanism of interfacing devices with nerves, as a result the device is able to precisely target the molecular mechanism that directly relates to the diseases via electrical signal reading and modulation. An example is to treat rheumatoid arthritis, an inflammatory disease, by electrical stimulation. In fact, this newly interdisciplinary field shares many aspects of the conventional neuromodulation (or implantable systems) which has not specifically aiming at molecular mechanism. Neuromodulation does lay solid foundation leading to the inception of bioelectronics medicine, especially in the technology revolution toward miniaturization and integration. The neuromodulation has been a major activity at the current Medtech industry. This talk will present the opportunity, technology challenge, applications for the bioelectronics medicine and its role at the future Medtech industry. I will also present bioelectronics medicine research on central, spinal cord, and autonomic nervous systems in my Biomimetic Research Lab at UCLA.
Wentai Liu received a B.S. degree from National Chiao-Tung University in Taiwan, a M.S. degree from National Taiwan University, and a Ph.D. from the University of Michigan. In 1983, he joined North Carolina State University, where he held the Alcoa Chair Professorship in electrical and computer engineering and was the founder of the Analog/Mixed-Mode Design Consortium. In 2003-2011, he was a professor in the electrical engineering at the University of California, Santa Cruz, where he was also the Campus Director of the NSF Engineering Research Center on Biomimetic Microelectronic Systems. Currently he is a Distinguished Professor at both the Bioengineering Department and Department of Electrical Engineering and Director of Chan Soon-Shiong Bionic Engineering Center at California NanoSystem Institute, University of California at Los Angeles. His research interests include neuro-engineering, neural prosthesis, brain-machine interface, bioelectronics. Since its early stages, he has been leading the engineering efforts of the retinal prosthesis to restore vision, leading to successful implant tests in blind patients. The venture finally leaded to successful commercial implants (code name as Argus-II) for blind patients, receiving both CE Mark in 2011 and USA FDA market approval in Feb 2013. He has published more than 300 technical papers and is a co-author of Wave Pipelining: Theory and CMOS Implementation (Kluwer Academic). He received 2009 R&D-100 Editor Choice Award, 2010 Popular Mechanics Breakthrough Invention Award, Outstanding Paper Awards from IEEE-CVPR (1986) and ACCV (2009) Conferences, Alcoa Foundation's Distinguished Engineering Research Award, NASA Group Achievement Award, and both Outstanding Alumni Award and Honorary Doctoral Degree from National Chiao-Tung University, Taiwan. He has served as guest editors for IEEE proceeding and IEEE Trans. on MTT and is currently an Associate Editor for IEEE Trans. on Bio-Circuits and Systems. He is also an ISSCC Subcommittee member as well as a co-founder of the International Conference on Neuroprosthetic Devices (ICNPD).
Prof. Yehea Ismail
CMOS Lab-on-a-chip for Mass Production of Affordable Diagnostic Chips
American University in Cairo/Zewail City of Science and Technology Center of Nanolectronics and Devices (CND) email@example.com/04/29 11:10 ~ 12:00 東館禮堂廳(5F)
Lab-on-a-chip is a technology which changed the traditional way by which biological samples are inspected in laboratories during analyses. This technology promises many advantages including better and improved performance, portability, reliability and cost reduction. A Lab-on-a-chip is composed of three main parts; actuation, sensing and electronics. Typically, hybrid technologies are used for the three parts, representing difficulties in integration and increased cost. However, Complementary Metal Oxide Semiconductor (CMOS) technology allows the functional integration of all parts including sensors, signal conditioning and processing circuits using a single homogeneous technology to develop a fully integrated lab-on-a-chip. CMOS technology is a very well established mass production and cheap technology. Hence, any viable lab-on-a-chip based on CMOS technology will have direct commercial value and application. This talk presents the general aspects and components of a CMOS Bio-chip, and illustrates the trends with specific examples of the speaker's research and other existing research. Moreover, this talk summarizes the challenges and the future trends in CMOS based lab-on-a-chip technology.
Yehea Ismail is the director of the Nanoelectronics and Devices Center at the American University in Cairo and Zewail City. He was a tenured professor with Northwestern University, USA from 2000 till 2011. Professor Ismail was the Editor-in-Chief of the IEEE Transaction on Very Large Scale Integration (TVLSI) 2011-2015 and the chair elect of the IEEE VLSI technical committee. He is on the editorial board of the Journal of Circuits, Systems, and Computers, was on the editorial board of the IEEE Transactions on Circuits and Systems I: Fundamental Theory and Applications, and a guest editor for a special issue of the IEEE Transactions on Very Large Scale Integration (VLSI) Systems on "On-Chip Inductance in High Speed Integrated Circuits". He has also chaired many conferences such as GLSVLSI, IWSOC, ISCAS. He was the Chief Scientist of the Innovation and Entrepreneurship Center of the Ministry of Communications and Information Technology, Egypt
Professor Ismail has several awards such as the USA National Science Foundation Career Award, the IEEE CAS Outstanding Author Award, Best Teacher Award at Northwestern University, and many other best teaching awards and best paper awards. Professor Ismail is the distinguished lecturer of IEEE CASS. He is an IEEE Fellow.
Professor Ismail has published more than 300 papers in top refereed journals and conferences and many patents. He co-authored seven books including: On-Chip Inductance in High Speed Integrated Circuits, Handbook on Algorithms for VLSI Physical Design, Temperature-Aware Computer Architecture, Arbitrary Modeling of TSVs for 3D Integrated Circuits, and Circuit Design Techniques for Microscale Energy Harvesting Systems. He has many patents in the area of high performance circuits and interconnect design and modeling. His work is some of the most highly cited in the VLSI area and is extensively used by industry.
- Ahmed El-Badawy, Marwa Amer, Reda Abdelbaset, Sameh N.Sherif, Marwan Abo-Elela, Yehya H.Ghallab, Hamdy Abdelhamid, Yehea Ismail, Nagwa El-Badri, "Adipose Stem Cells Display Higher Regenerative Capacities and More Adaptable Electro-Kinetic Properties Compared to Bone Marrow-Derived Mesenchymal Stromal Cells", Springer Nature Research Journal, November 2016.
- Ghallab, Y.H.; Abd El-Hamid, H.; Ismail, Y., "Lab on a Chip Based on CMOS Technology: System Architectures, Microfluidic Packaging, and Challenges," in Design & Test, IEEE , vol.32, no.6, pp.20-31, Dec. 2015 doi: 10.1109/MDAT.2015.2491785 Ahmad Qassem, Reda Mohamed, Yehya Ghallab, Yehea Ismail, "A 130 nm CMOS Integrated Lab-On-a-Chip Based on DeFET Sensor for Biomedical Analysis", MWSCAS 2016, October 2016, Abu Dhabi
- Reda Abdelbaset, Yehya Ghallab, Hamdy Abdelhamid, Yehea Ismail and Mohamed Elwakad, "A 2D Model of Traveling Wave Dielectrophoresis Microelectrode Array based on Printed Circuit Board Technology for manipulation and characterization of Malignant and Normal Liver Cells", Fourth International Japan-Egypt Conference on Electronics, Communications and Computers (JEC-ECC 2016)
- Yehya H. Ghallab and Yehea Ismail" CMOS Based Lab-on-a-chip: 'Applications, Challenges and Future Trends", published at IEEE Circuit and Systems Magazine, pp. 27-47, Q2 issue, June 2014.
Dr. Po-Kang Lin
Porcine Electroretinography and Histology after Long-Term Implantation of Division-Power-Supply-Scheme Photovoltaic Subretinal Prostheses
Taipei Veterans General Hospital, Taiwan Department of Ophthalmology firstname.lastname@example.org/04/30 09:20 ~ 10:40 東館禮堂廳(5F)
Introduction: For several kinds of retinal degenerative disorders, there is no cure yet, for example, retinitis pigmentosa. The patients will be blind. Fetus retinal cells transplantation, stem cells transplantation, or gene therapy may possibly provide therapeutic efficacy in the future. However, currently the only available approach is retinal prosthesis. Many study groups in the world are devoted to this field, but only two products are on market yet. One is epiretinal device and the other is subretinal device, both requiring wired power supply within the eye. Alternatively, our approach is wireless.
Purpose: To demonstrate the electroretinography (ERG) and histology of eyes of minipig after long-term bimplantation of wireless photovoltaic subretinal prostheses.
Methods: A series of the retinal prosthesis chip was designed and fabricated. Among the prostheses were an 8x8 pixels and another 16x16 pixels array. Each pixel was fabricated with parallel micro photodiodes, equipped with a pair of an independent output electrode and an adjacent return electrode. The prostheses were powered by on-chip solar cells, and embedded with a unique circuit, i.e. division-power-supply-scheme (DPSS), inspired by flicker fusion. Some of the prostheses were further packed with hermetic packaging. The prostheses were examined through a series of biosafety and biocompatibility tests. The photovoltaic subretinal prostheses were implanted to minipigs. Mostly, the implantation was performed through the choroid approach. ERG was performed with different protocols (Roland, Germany). Histological examination was done after enucleation.
Results: The 8x8 pixels array prostheses had been implanted for 2 years, and the 16x16 pixels array for 7 months. The prostheses stayed well in the subretinal space of the posterior fundus. ERG showed significant b-wave responses after bleaching in the implanted eye, whereas the control eye showed flat response. The histological examination showed relatively preserved inner layer of the retina.
Conclusions: The electrophysiology and biocompatibility of a novel 64 pixels and a 256 pixels photovoltaic subretinal prosthesis with DPSS are primarily verified through the long-term implantation to minipigs. The prostheses bear potential to enter future clinical trials.
Po-Kang Lin, MD was graduated from National Yang Ming University, ROC, 1985. He was a resident, chief resident, and a research fellow in Taipei Veterans General Hospital, ROC from 1987-1990, 1990-1991, 1991-1993, respectively. Since 1993, Doctor Lin has been a retina staff in the Department of Ophthalmology in Taipei Veterans General Hospital, ROC. From 1994 to1995, he was a research fellow in Columbia University, USA. Now he is a researcher of the Biomedical Electronics Translational Research Center (BETRC), National Chiao Tung University, ROC. He is also a clinical professor in National Defense Medical University, ROC, since 2012, and an associate professor of ophthalmology in National Yang Min University. His current research fields are clinical ophthalmology, biomedical electronics, focused-ion-beam for biology, and retina: biological, medical, and surgical.
- Hui-Chen Cheng, Shui-Mei Lee, Fenq-Lih Lee, Jorn-Hon Liu, Chieh-Hsiung Kuan, Po-Kang Lin*. 2013. Short-term external buckling with pneumatic retinopexy for retinal detachment with inferior retinal breaks. American Journal of Ophthalmology 155(4): 750-756. (correspondent)
- Po-Kang Lin*, Chia-Ying Ke, Chin-Ni Khor, Yu-Jyun Cai, Yih-Jing Lee*. 2013. Involvement of SDF1a and STAT3 in granulocyte colony-stimulating factor rescues optic ischemia-induced retinal function loss by mobilizing hematopoietic stem cells. Investigative Ophthalmology & Visual Science 54(3): 1920-1930
- Hui-Chen Cheng, Jorn-Hon Liu, Shui-Mei Lee, Po-Kang Lin*. 2014. Hyperhomocysteinemia in Patients with Polypoidal Choroidal Vasculopathy: A Case Control Study. PLoS ONE 9(10): e110818. (correspondent)
- Shih-Yun Lee, Wei-Kuang Yu, Po-Kang Lin*. 2015. Large Gene Deletion and Changes in Corneal Endothelial Cell in a Family with Choroideremia. Investigative Ophthalmology & Visual Science 56(3): 1887-1893. (correspondent)
- Hui-Chen Cheng, Shui-Mei Lee, Yi-Ting Hsieh, Po-Kang Lin*. 2015. Efficacy of intravitreal injection of anti-vascular endothelial growth factor agents for stage 4 retinopathy of prematurity. RETINA-The Journal of Retinal and Vitreous Diseases 35(4): 660-666. (correspondent)
Dr. Chia-Fone Lee
The Cochlear Implant in the Future
Hualien Tzu Chi Hospital Department of Otolaryngology email@example.com/04/30 09:20 ~ 10:40 東館禮堂廳(5F)
Hearing aids for patients with hearing aids used in the traditional hearing aid. The latest technology, "artificial ear," its English name cochlear implant, also known as "artificial cochlea", refers to the implantable cochlea by surgery an electronic device, the device can be discharged directly through the current Stimulate the auditory nerve and produce hearing. However, the artificial ear implantation technology in the 1950s gradually matured, the latest technology can be aids, for hearing aid is not helpful for patients with severe hearing loss, the artificial ear implant technology to help this Group of hearing impaired patients, to regain hearing, improve their communication skills, thereby promoting social adaptation, and to make their professional ability to play, the magic of medical utility is vigorously promoted. As the artificial ear implantation technology advances, can benefit more patients with hearing impairment, according to statistics, there are more than a thousand domestic hearing impaired patients to receive artificial electronic ear implant technology, and the world has tens of thousands of people in the The device is a manual electronic ear.
The working principle of the artificial ear is based on the frequency topology of the cochlea (Tonotopy). Frequency topology is a regular relationship between different parts of the cochlea and different sound frequencies. In normal hearing systems, the mechanical vibration of the sound through the outer ear and middle ear, in the cochlea within the liquid within the tube to form a traveling wave, traveling wave in the cochlea throughout the basement membrane resonance. According to the frequency of different basement membrane in different parts of the maximum amplitude of resonance. The high-frequency sound produces a maximum resonance amplitude at the base film near the bottom (i.e., near the round window), and the maximum resonance amplitude of the low-frequency sound is produced at the portion of the base film near the top (i.e., away from the window). The vibrations of the basement membrane drive hair cell cilia vibration to produce hair cell receptor potential, thereby generating the auditory nerve action potential release. The auditory nerve inherits the frequency topological properties of the cochlea. The frequency topology is a means by which the auditory system decomposes the sound into different frequency components. Brain central auditory system can be based on the auditory nerve in the distribution of different nerve fibers to determine the basement membrane vibration, and the frequency of sound components. Genetic factors, the role of ototoxic drugs, meningitis disease, as well as by the noise of the destruction of noise, are caused by some patients with sensory nerve deafness, hair cells were reduced or the number of possible causes of injury. Remnant hair cells can't properly stimulate the auditory nerve. The cochlear implant is to bypass the hair cells in this part of the direct electrical stimulation of the auditory nerve. For the brain, the electrical stimulus works as if the auditory nerve is being driven by the normal basal membrane and hair cells. This is the basic working principle of artificial electronic ears.
When a person's hearing loss, while other hearing aids without a big help, they should consider using artificial electronic ear. Especially hearing impaired children, can't help with hearing aids, should be considered as soon as possible to accept artificial electronic ear implantation surgery, usually hearing the shorter the time the better. If prolonged, especially for children with complete deafness, will increase the difficulty of post-operative education, and reduce the effect after surgery. Taiwan has entered the aging society, many elderly people have hearing problems, however, not everyone is suitable for hearing aids to wear. Physicians pointed out that the hearing loss of more than 80 decibels or more, the best choice of artificial ear, domestic artificial ear technology is mature, using minimally invasive surgery, postoperative wound is not swollen to revitalize the hospital for nearly 10 years 350 cases The youngest only 10 months, the largest is 86 years old, all patients are not present infection problems, the success rate of 100%, more land-based from Heilongjiang, Inner Mongolia and other places come here especially. Last year, the Department of Health subsidized newborns within 36 hours after birth, hearing screening, help early detection, and the artificial ear surgery, the Department of Health only subsidize children under the age of 6, the elderly are not subsidized.
Keyword: Artificial ear, hearing aid, hearing impairment, hearing examination
National Taiwan University
Ph.D. in Graduate Institute of biomedical Engineering
National Taiwan University
B.E. in Medicine
|Academic and Industry Experience|
Associate Professor, Medical Department
Tzu Chi University
Assistant Professor, Medical Department
Tzu Chi University
Visiting Staff, Otolaryngology Department
Buddhist Tzu Chi General Hospital
|2008||A novel opto-electromagnetic actuator coupled to the tympanic membrane.|
- Lee Chia-Fone, Chen Peir-Rong, Lee Wen-Jeng, Chen Jyh-Horng, Liu Tien-Chen, "Three-dimensional reconstruction and modeling of middle ear biomechanics by high-resolution computed tomography and finite element analysis", Laryngoscope (SCI), 116: 711-716, 2006.
- Lee Chia-Fone, Chen Jyh-Horng, Chou Yuan-Fang, Hsu Lee-Ping, Chen Peir-Rong, Liu Tien-Chen, "Optimal graft thickness for different sizes of tympanic membrane perforation in cartilage myringoplasty: a finite element analysis", Laryngoscope (SCI), 117:725-730, 2007.
- Lee Chia-Fone, Hsu Lee-Ping, Chen Peir-Rong, Chou Yuan-Fang, Chen Jyh-Horng, Liu Tien-Chen, "Biomechanical modeling and design optimization of cartilage myringoplasty using finite element analysis", Audiology & Neurotology (SCI), 11: 380-388, 2006.
- Lee Chia-Fone, Chen Peir-Rong, Lee Wen-Jen, Chou Yuan-Fang, Chen Jyh-Horng, Liu Tien-Chen, "Computer aided modeling of human mastoid cavity biomechanics using finite element analysis, "EURASIP Journal on advances in Signal Processing. Special Issue: Image processing and analysis in biomechanics (SCI), 1-9: 2009.
- Lee Chia-Fone, Li Gen-Jia, Wan Shu-Yen, Lee Wen-Jeng, Tzen Kai-Yuan, Chen Chiung-Hsiang, Song Yu-Lin, Chou Yuan-fang, Chen Yuh-Shyang, Liu Tien-Chen," Registration of micro-computed tomography and histological images of guinea pig cochlea to construct an ear model using an iterative closet point algorithm", Annals of biomedical Engineering (SCI), 38(5): 1717-1727, 2010.
Dr. Yue-Loong Hsin
Neuromodulation for Epilepsy
Chung Shan Medical University Hospital Department of Neurology2017/04/30 09:20 ~ 10:40 東館禮堂廳(5F)
A significant proportion of epilepsy patients is medically refractory and apart from those who are candidates for resective surgery, most will continue to have disabling seizures for rest of their lives.
Neuromodulation, or neurostimulation, is a palliative treatment option for many of these patients who are not eligible for resective surgery or who have persistent medically intractable refractory seizures despite previous epilepsy surgery. Patients typically have partial onset seizures, with or without secondary generalization, or less frequently, generalized epilepsies. Candidates for neuromodulation usually have a long-standing history of intractable epilepsy and have undergone extensive investigations, including video- electroencephalography (EEG), advanced neuroimaging, and even intracranial subdural or depth electrode implantations for seizure localization in many cases. Most of these patients have been found to have no single discrete seizure onset localization; a minority has seizure onsets localized to indispensable areas of eloquent cortex, for example, within the boundaries of language centers in the dominant temporal or frontal cortices. Neuromodulation as an alternate form of treatment for intractable epilepsy was first considered based on historical observations that electrical stimulation of subcortical structures could modify the cortical EEG: high-frequency stimulation "de- synchronized" the EEG and low-frequency stimulation "synchronized" the EEG. Increased cortical synchrony mediated by low-frequency stimulation was demonstrated to be proepileptic, while cortical desynchronization mediated by high-frequency stimulation was shown to be anti- epileptic.
In this talk, some historical highlights of the surgery of epilepsy will be reviewed. The current available tools as neuromodulation for seizure control will be addressed. In addition, emerging techniques will be introduced. However, further development and clinical experience to optimize the place of non-medical therapy are required.
Dr. Yue-Loong Hsin graduated in 1986 from medicine of school, Kaohsiung medical university. In 1998, he finished his residency training of neurology and was qualified as neurology specialist. Since he visited department of brain pathophysiology at Kyoto University in 1999, he focused on treatment of epilepsy and neurophysiology research about epilepsy. After Dr. Harnod Tomor became a member of neuroscience center at Hualien Tz Chi hospital, the first epilepsy surgery was conducted in 2000. By far, over 100 patients underwent epilepsy surgeries and had significant improvement of seizure control. Besides, clinical and basic researches about the pathophysiology of epilepsy are also in progress. Moreover, Dr. Hsin is interested in studying the temporospatial dysnamics of epileptic activity and connectivity of normal and abnormal brain functions. Currently he is the chairman of neurologic department at Chung Shan Medical University.
- S.-J. Peng, T. Harnod, J. Z. Tsai, C. C. Huang, M. D. Ker, J. C. Chiou, H. Chiueh, C. Y. Wu and Y. L. Hsin, "Through diffusion tensor magnetic resonance imaging to evaluate the original properties of neural pathways of patients with partial seizures and secondary generalization by individual anatomic reference atlas," Biomed. Res. Int., vol. 2014, pp. 419376, 2014.
- S.-J. Peng, T. Harnod, J. Z. Tsai, M. D. Ker, J. C. Chiou, H. Chiueh, C. Y. Wu and Y. L. Hsin, "Evaluation of subcortical grey matter abnormalities in patients with MRI-negative cortical epilepsy determined through structural and tensor magnetic resonance imaging," BMC Neurol., vol. 14, pp. 104-2377-14-104, May 14, 2014.
- J. Z. Tsai, S.-J. Peng, Y. W. Chen, K. W. Wang, C. H. Li, J. Y. Wang, C. J. Chen, H. J. Lin, E. E. Smith, H. K. Wu, S. F. Sung, P. S. Yeh and Y. L. Hsin, "Automated segmentation and quantification of white matter hyperintensities in acute ischemic stroke patients with cerebral infarction," PLoS One, vol. 9, pp. e104011, Aug 15, 2014.
- J. Z. Tsai, S.-J. Peng, Y. W. Chen, K. W. Wang, H. K. Wu, Y. Y. Lin, Y. Y. Lee, C. J. Chen, H. J. Lin, E. E. Smith, P. S. Yeh and Y. L. Hsin, "Automatic detection and quantification of acute cerebral infarct by fuzzy clustering and histographic characterization on diffusion weighted MR imaging and apparent diffusion coefficient map," Biomed. Res. Int., vol. 2014, pp. 963032, 2014.
- S.-J. Peng and Y.-L. Hsin, "Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures," NeuroImage: Clinical, vol. 13, pp. 55-61, 2016.
Dr. Chiung-Chu Chen
Deep brain stimulation for Parkinson's disease: present and future
Chang Gung Memorial Hospital Department of Neurology. firstname.lastname@example.org https://www.cgmh.org.tw/doctor/2931.htm2017/04/30 09:20 ~ 10:40 東館禮堂廳(5F)
Deep brain stimulation (DBS) is an effective treatment for patients with advanced Parkinson's disease (PD). However, the therapeutic efficacy is often limited by partial improvement of symptoms, unwanted side effects and expensive costs. A more economic and sensible stimulation should only be triggered and delivered on demand when certain biomarker excess the threshold.
Increasing evidence showed that Parkinsonism symptom is associated with neuronal activities oscillating at β band (13-35 Hz) at subcortical level. The aim of this project is to apply a novel closed-loop DBS to patients with its stimulation triggered by β band local field potentials (LFP) recorded from subcortical, as well as to examine whether the new system is more effective than the conventional DBS.
In this talk, the current status of DBS therapy for PD and the possible development of new closed-loop DBS will be discussed.
|1988-1995||China Medical University, Taichung, Taiwan-MD|
|2004-2008||Institute of Neurology, UCL, UK-Ph.D|
|2004||Research fellow at Inserm 318, Joseph-Fourrier University, Grenoble, France|
|2003-2004||Research fellow at Imperial College, London, UK|
|Supervisor of MSc in Institute of Neurology, UCL, UK|
|2012~||Associate Professor, Chang Gung University, Taiwan|
|2000~||Attending doctor, Department of Neurology, Chang Gung Memorial Hospital, Taiwan|
|1999~2000||Fellow in Department of Neurology, Chang Gung Memorial Hospital, Taipei, Taiwan|
|1995~1999||Resident doctor in Department of Neurology, Chang Gung Memorial Hospital, Taiwan|
- Chen CC*, Lin WY*, Chan HL, Tu PH, Lee ST, Lu CS, Brown P., "The impact of low-frequency stimulation of subthalamic region on self-generated isometric contraction in patients with Parkinson's disease.", Experimental Brain Research, 2013; 227(1):53-62.
- Chen CC*, Wey Yil Lin*, Hsiao Lung Chan, Yi Ting Hsu, Po Hsun Tu, Shih Tseng Lee, Shang Ming Chiou, Chon Haw Tsai d, Chin Song Lu and Peter Brown., "Stimulation of the subthalamic region at 20 Hz slows the development of grip force in Parkinson's disease.", Experimental Neurology, 2011; 231(1):91-6.
- Chen CC*, Hsu YT, Chan HL, Chiou SM, Tu PH, Lee ST, Tsai CH, Lu CS, Brown P., "Complexity of subthalamic 13-35 Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease", Experimental Neurology, 2010 ;224(1):234-40.
- Chen CC, Bruck C, Kempf F, Kupsch A, Lu CS, Lee ST, Tisch S, Limousin P, Hariz M and Brown P.*, "Deep brain stimulation of the subthalamic nucleus: a two edged sword", Current Biology, 2006; 16(22):R952-3.
- Brown P*, Chen CC, Wang S, Kuhn A, Doyle L, Yarrow K, Stin J, Aziz T., "Involvement of human Basal Ganglia in off-line feed-back control of voluntary movement", Current Biology, 2006; 16(21):2129-34.
Fundamentals of Power-Efficient Reconfigurable Analog Sensing Front-End Circuits for Biomedical Applications: Models, Components, and Circuits
National Taiwan University of Science and Technology Electrical Engineering email@example.com/04/28 14:00 ~ 15:30 茉莉廳(3F)
Low-power analog front-end (AFE) circuits are crucial building blocks in many wearable and implanted sensing devices for a variety of biomedical applications. To achieve low power consumption, circuit designers prefer bias MOS transistors in the subthreshold region, of which operating principles are seldom covered in undergraduate textbooks. This tutorial begins with the introduction of the EKV model, which is a bulk-referenced model and has been widely used in low-power analog circuit design. Transistor noise model is then presented to provide guidelines in designing low-noise circuits. Besides low-power consumption, reconfigurability is another desired feature in developing analog sensing front-end circuits. It is more economical to design and to fabricate a hardware that can be programmed to fit in different using scenarios. Since floating-gate transistors have been employed in developing reconfigurable power-efficient analog circuits and systems, the tutorial also briefs the structure and operating principles of floating-gate transistors. Finally, some low-power reconfigurable circuits are illustrated to shed light on design insight and techniques for low-noise amplifiers, reconfigurable filters, and power-efficient voltage regulators.
Sheng-Yu Peng received the B.S. and M.S. degrees in Electrical Engineering from the National Taiwan University, Taipei, Taiwan, in 1995 and 1997 respectively; a degree of Master of Science in Electrical and Computer Engineering from the Cornell University, Ithaca, NY, in 2004; and the Ph.D. degree in Electrical and Computer Engineering from the Georgia Institute of Technology, Atlanta, GA, in 2008. From 2008 to 2011, he worked for GTronix Inc. and MaxLinear Inc. respectively.
Dr. Peng joined the National Taiwan University of Science and Technology, Taipei, Taiwan, in 2011. Currently he is an Associate Professor in the Department of Electrical Engineering. His research interests include interface circuits for sensors, reconfigurable analog circuits and systems, power-efficient analog signal processing, and low-power machine learning algorithms.
- S.-Y. Peng*, L.-H. Liu, P.-K. Chang, T.-Y. Wang, and H.-Y. Li, "A Power-Efficient Reconfigurable Output-Capacitor-Less Low-Drop-Out Regulator for Low-Power Analog Sensing Front-End," IEEE Transactions on Circuits and Systems I: Regular Papers, accepted in Apr. 2016. (SCI, EI) (Impact factor: 2.403, Rank factor: 39/249, (ENGINEERING, ELECTRICAL & ELECTRONIC))
- T.-Y. Wang, L.-H. Liu, and S.-Y. Peng*, "A Power-Efficient Highly-Linear Reconfigurable Biopotential Sensing Amplifier Using Gate-Balanced Pseudo Resistors," IEEE Transactions on Circuits and Systems II: Express Briefs, vol. 62, no. 2, pp. 199-203, Feb. 2015. (SCI, EI) (Impact factor: 1.234, Rank factor: 126/249, (ENGINEERING, ELECTRICAL & ELECTRONIC))
- T.-Y. Wang, M.-R. Lai, C. M. Twigg, and S.-Y. Peng*, "A Fully Reconfigurable Low-Noise Biopotential Sensing Amplifier With 1.96 Noise Efficiency Factor," IEEE Transactions on Biomedical Circuits and Systems, vol. 8, no. 3, pp. 411-422, June 2014. (SCI, EI) (Impact factor: 2.482, Rank factor: 34/249, (ENGINEERING, ELECTRICAL & ELECTRONIC))
- S.-Y. Peng*, M. S. Qureshi, P. E. Hasler, A. Basu, and F. L. Degertekin, "A Charge-Based Low-Power High-SNR Capacitive Sensing Interface Circuit," IEEE Transactions on Circuits and Systems I: Regular Papers, Vol. 55, No. 7, pp. 1863 – 1872, Aug. 2008. (SCI, EI) (Impact factor: 2.043, Rank factor: 56/229, (ENGINEERING, ELECTRICAL & ELECTRONIC))
- S.-Y. Peng*, P. E. Hasler, and D. V. Anderson, "An Analog Programmable Multidimensional Radial Basis Function Based Classifier," IEEE Transactions on Circuits and Systems I: Regular Papers, Vol. 54, No. 10, pp. 2148 – 2158, Oct. 2007. (SCI, EI) (Impact factor: 1.204, Rank factor: 66/227, (ENGINEERING, ELECTRICAL & ELECTRONIC))
Behavior computing for health applications
National Tsing Hua University Electrical Engineering firstname.lastname@example.org http://biic.ee.nthu.edu.tw2017/04/28 15:50 ~ 17:20 茉莉廳(3F)
The abstraction of humans with a signals and systems framework naturally brings a synergy between engineering and behavioral sciences. Behavioral signal processing (BSP) offers a new frontier of interdisciplinary research between these communities. The core research in BSP is to compute human behaviors with observational data by using methods grounded in signal processing and machine learning with applications contextualized in cross-disciplinary domains. The outcome of BSP offers novel analytics to enhance the decision-making capabilities of domain experts. In this talk, we will briefly describe the use of behavioral computing techniques in a variety of health applications given heterogeneous type of data: speech, video, and personal records. With this emerging effort of BSP, we strive not only to provide engineering solutions to domain experts but also to open up potential opportunities of novel insights in applications of broad societal impact.
Jeremy is an assistant professor at National Tsing Hua University, Taiwan. He has been a member of Signal Analysis and Interpretation Laboratory (SAIL) at USC directed by Prof. Shrikanth Narayanan and obtained his PhD degree in Electrical Engineering in December 2012. Jeremy was a data scientist at id:a lab at ID Analytics, inc from Feb. 2013 - Dec. 2013. His research interests are in human-centered behavioral signal processing, emphasizing the development of computational frameworks in recognizing and quantifying human behavioral attributes and interpersonal interaction dynamics using machine learning and signal processing techniques. He has been involved in multiple interdisciplinary research projects and has conducted collaborative research with researchers across domains of behavioral sciences.
- Daniel Bone, Chi-Chun Lee, Matthew Black, Marian Williams, Sungbok Lee, Pat Levitt, and Shrikanth S. Narayanan, "The Psychologist as an Interlocutor in ASD Assessment: Insights from a Study of Spontaneous Prosody", in: Journal of Speech, Language, and Hearing Research, 57(4): 1162-77, 2014, doi: 10.1044/2014_JSLHR-S-13-0062
- Chi-Chun Lee, Athanasios Katsamanis, Matthew Black, Brian Baucom, Andrew Christensen, Panayiotis G. Georgiou, and Shrikanth S. Narayanan, "Compute Vocal Entrainment: A Signal-Derived PCA-based Quantification Scheme with Application for Affect Analysis in Married Couple Interactions ", in: Journal of Computer Speech and Language, 28(2): 518-539 doi:10.1016/j.csl.2012.06.006
- Fu-Sheng Tsai, Ya-Ling Hsu, Wei-Chen Chen, Yi-Ming Weng, Chip-Jin Ng,Chi-Chun Lee, "Toward Development and Evaluation of Pain Level-Rating Scale for Emergency Triage based on Vocal Characteristics and Facial Expressions" in Proceedings of the International Speech Communication Association (Interspeech), 2016
- Hsuan-Yu Chen, Yu-Hsien Liao, Heng-Tai Jan, Li-Wei Kuo, Chi-Chun Lee, "A Gaussian Mixture Regression Approach toward Modeling the Affective Dynamics between Acoustically-derived Vocal Arousal Score (VC-AS) and Internal Brain fMRI BOLD Signal Response" in Proceedings of the International Conference on Acoustics, Speech, and Signal Processing (ICASSP), 2016
- Shan-Wen Hsiao, Hung-Ching Sun, Ming-Chuan Hsieh, Ming-Hsueh Tsai, Hsin-Chih Lin, Chi-Chun Lee, "A Multimodal Approach for Automatic Assessment of School Principals' Oral Presentation During Pre-service Training Program" in Proceedings of the International Speech Communication Association (Interspeech), 2015
Animal Models for Biomedical Research
Yuanpei University of Medical Technology Department of Nursing email@example.com/04/28 14:00 ~ 15:30 荷花廳(3F)
|1998/09 至 2006/06||中國醫藥大學 藥物化學研究所 博士|
|1995/09 至 1997/06||中國醫藥學院 環境醫學研究所 碩士|
|1982/09 至 1987/06||中國醫藥學院 藥學系 學士|
|藥理學 生理學 藥物動力學 豬模式動物試驗 外科學|
- Chin-Yu Lin, Yao-Horng Wang, Kuei-Chang Li, Li-Yu Sung, Chia-Lin Yeh, Kun-Ju Lin, Tzu-Chen Yen, Yu-Han Chang, Yu-Chen Hu. 2015. Healing of massive segmental femoral bone defects in minipigs by allogenic ASCs engineered with FLPo/Frt-based baculovirus vectors. Biomaterials 50: 98-106. (SCI: IF=8.312, based on 2013 JCR)
- Yuan-Hung Liu, Kai-Yen Peng, Yu-Wei Chiu, Yi-Lwun Ho, Yao-Horng Wang, Chia-Tung Shun, Shih-Yun Huang, Yi-Shuan Lin, Antoine A.F. de Vries, Daniël A. Pijnappels, Nan-Ting Lee, B. Linju Yen, Men-Luh Yen. 2015. Human Placenta-Derived Multipotent Cells (hPDMCs) Modulate Cardiac Injury: From Bench to Small & Large Animal Myocardial Ischemia Studies. Cell Transplantation 24:2463–2478. (SCI: IF=3.570, based on 2013 JCR)
- Shao-Yu Peng, Yu-Shi Chen, Chih-Jen Chou1, Yao-Horng Wang, Hung-Maan Lee, Winston Teng-Kui Cheng, SW Steven Shaw, Shinn-Chih Wu. 2014. Cell fusion phenomena detected after in utero transplantation of Ds-red-harboring porcine amniotic fluid stem cells into EGFP transgenic mice. Prenatal Diagnosis 5:487-495. (SCI: IF=2.514, ranking on top 20%=16/78, based on 2013 JCR; subject categories of OBSTETRICS & GYNECOLOGY).
- Chun-Li Wang, Ching-Kuei Chen, Yao-HorngWang, and Yu-Wen Cheng. 2014. In Search of the Active Metabolites of an Anticancer Piperazinedione, TW01003, in Rats. BioMed Research International 2014 Article ID 793504, 6 pages. http://dx.doi.org/10.1155/2014/793504
- Chia-Chun Chen, Cheng-Hao Liao, Yao-Horng Wang, Yuan-Ming Hsu, Shih-Horng Huang, Chih-Hung Chang, and Hsu-Wei Fang. 2012. Cartilage fragments from osteoarthritic knee promote chondrogenesis of mesenchymal stem cells without exogenous growth factor induction. J Orthop Res 30:393–400 (SCI: 2.875)
Prof. Yih-Jing Lee
Essential neurophysiology and animal models for neural degenerative diseases
Fu-Jen Catholic University, Taiwan School of Medicine firstname.lastname@example.org http://pbl.med.fju.edu.tw/med/teacher_detial.asp?id=202017/04/28 15:50 ~ 17:20 荷花廳(3F)
In this tutorial section, there will be two subjects presented: one is the basic concept of neurophysiology, and the other one is animal models used for researches in neural degenerative diseases. In order to communicate signals between cells in the human body, the nervous system was developed. The nervous system, which is a rapid control system, regulates most internal body functions and coordinates the activities we collected as human behavior. These activities comprise mediating of sensation, controlling movement, and encoding multifarious human mind. The nervous system is composed of trillions of glial cells and neurons in a network throughout the brain, spinal cord, and peripheral. These neurons can simply transduced by an electrical stream causing transmitters released from neurons. The structure and individual nerve cells, the chemical and electrical mechanisms underlying nerve cell function, and the basic organization of the nervous system would be discussed in this section.
Since neurons are delicate and un-regenerable, neural degenerative diseases become major problems in neurological clinic. These neural degenerative diseases, such as Alzheimer's disease, Parkinson's disease, and stroke, are usually found difficult to slow down the progress of the disease, and there is still no effective way to regain the function loss of the degenerative cells. It is therefore many researches aim on solving problems in the pathogenesis and therapy on these diseases. We will introduce animals models commonly used for these neural degenerative diseases in this section.
|Ph.D.||Department of Physiology,King's College London, University of London, UK|
|M.S.||Graduate Institute of Medical Science, Taipei Medical University, Taiwan|
|B.S.||School of Pharmacy, Taipei Medical University, Taiwan|
|2015~present||Vice Dean, Office of Research and Development, Fu-Jen Catholic University, Taiwan,|
|2014~present||Professor, School of Medicine, Fu-Jen Catholic University, Taiwan|
|2010~2014||School of Medicine, Fu-Jen Catholic University, Taiwan, Associate Professor|
|2001~2010||Assistant Professor, School of Medicine, Fu-Jen Catholic University, Taiwan|
|2000~2001||Post-doctoral Research Associate, Department of Pharmacology, University of Cambridge, UK|
|2000||Research Assistant, Centre for Neuroscience Research, King's College London, UK|
- Cheng CK, Peng PH, Tien LT, Cai YJ, Chen CF, and Lee YJ* (2009): Bevacizumab is not toxic to retinal ganglion cells after repeated intravitreal injection. Retina, 29: 306-312. (SCI)
- Hsiao WT, Tsai MD, Jow GM, Tien LT, and Lee YJ* (2012): Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. Molecular Vision, 18: 2033-2042. (SCI)
- Tsai MD, Chen PR, Tien LT, Cai YJ, and Lee YJ* (2013): Nuclear condensation and cell cycle arrest induced by telomerase siRNA in neuroblastoma cells. Journal of Neuro-Oncology, 111: 265-272. (SCI)
- Lin PK, Ke CY, Khor CN, Cai YJ, and Lee YJ* (2013): Involvement of SDF1a and STAT3 in granulocyte colony-stimulating factor rescues optic ischemia-induced retinal function loss by mobilizing hematopoietic stem cells. Investigative Ophthalmology & Visual Science, 54: 1920-1930. (SCI)
- Cheng YP, Ke CY, Kuo CC, and Lee YJ* (2016): Effect of a complex lutein formula in an animal model for light-induced retinal degeneration. The Chinese Journal of Physiology, 59: 202-209. (SCI)
2017/04/30 11:00 ~ 12:00 東館禮堂廳(5F)Panel Discussion Session:
Digital Electronic Medicine and Taiwan's OpportunitiesChairman:
Peter (Chung-Yu) Wu (吳重雨), Chair Professor, National Chiao Tung UniversityPanelists:
- Wentai Liu (劉文泰), Professor, UCLA
- Chiung-Chu Chen (陳瓊珠), Doctor, Chang Gung Memorial Hospital
- Yue-Loong Hsin (辛裕隆), Doctor, Chung Shan Medical University Hospital
- Chia-Fone Lee (李家鳳), Doctor, Hualien Tzu Chi Hospital
- Po-Kang Lin (林伯剛), Doctor, Taipei Veterans General Hospital, Taiwan
In this panel discussion session, the panelists will share their visions and experiences on the development of the emerging field of digital electronic medicine. This field includes implantable closed-loop neuromodulation systems, brain science and engineering, combined implantable devices and medicines, and many other related new emerging sciences and technologies. In this emerging and growing field, what are Taiwan's opportunities? With the leading semiconductor technologies, ICT technologies, and outstanding medical sciences in Taiwan, how to catch up with the new opportunities and build up the industry? What are bottlenecks and barriers? What are the suitable business models? The audience and the panelists will discuss these issues through brainstorming and interactions.